Unit of Cellular Physiopathology
Lab of Cellular Physiopathology
tel. +051 2094131
fax +051 2094286
Group Leader: GIOVANNA BARTOLINI
E-mail : giovanna.bartolini@unibo.it
Research in progress :
- 1) Matrix metalloproteinases (MMPs) and their role in tumour diffusion. The expression and the activity of MMPs in cancer cell lines (glioblastoma, fibrosarcoma, colon carcinoma, etc.) are evaluated in basal conditions and in the presence of antitumoral compounds, such as retinoids. The correlation between the increase in MMPs and cyclooxygenase-2, the key enzyme in eicosanoid biosynthesis, is also studied.
- 2) Multi-drug resistance (MDR). In tumour cell lines, in which resistance to doxorubicin is associated to resistance to the retinoids presently in clinical use (all trans retinoic acid and 9-cis retinoic acid), the effect of newly synthesised retinoids is tested, in order to evaluate their antitumoral effect and to check if their action is accompanied by modifications of some markers of MDR, e.g., MRP and EMMPRIN proteins.
Funding :
- Progetto pluriennale di Ateneo (2003-2005)
- Meccanismi e segnali molecolari della sopravvivenza cellulare
Patents :
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Selected Publications :
- G.Bartolini, K.Ammar, B.Mantovani, F.Scanabissi, A.M.Ferreri, P.Rocchi e M.Orlandi. 2004 Retinoids and cancer: Antitumoral effect of ATRA and of the new derivative of retinoic acid, IIF, on colon carcinoma cell lines CaCo-2 and HT-29. Anticancer Res. 24: 1779-1784
- M.Orlandi, B.Mantovani, K.Ammar, E.Avitabile, P.Dal Monte e G.Bartolini. 2003 Retinoids and cancer: antitumoral effects of ATRA, of 9-cisRA and of the new retinoid IIF on HL-60 leukemic cell line. Med.Princ. Pract. 12: 164-169
- G.Bartolini, M.Orlandi, K.Ammar, E.Magrini, A.M.Ferreri e P.Rocchi. 2003 Effect of a new derivative of retinoic acid on proliferation and differentiation in human neuroblastoma cells. Anticancer Res. 23: 1495-1500
- A.M.Ferreri, G.Bartolini, M.Orlandi, K.Ammar e P.Rocchi. 2002 Differentiation promoting and antimitotic activities of a new derivative of retinoic acid on human neuroblastoma cells. Proc. 21st Annual Meeting of the European Society for Therapeutic Radiology and Oncology. Prague (Czeck Republic), Sept.17-21 -
- A.M.Ferreri, E.Magrini, G.Bartolini, M.Orlandi, K.Ammar, P.Perocco e P.Rocchi. 2001 Effectiveness of a new derivative of retinoic acid as differentiating agent on human neuroblastoma cells. Proc. European Cancer Conference. . Lisbon (Portugal), Oct. 21-25 -
- E.Spisni, C.Griffoni, S.Santi, M.Riccio, R.Marulli; G.Bartolini, M.Toni, V.Ullrich, V. Tomasi. 2001 Co-localization of prostacyclin (PGI2) synthase-caveolin 1 in endothelial cells and new roles for PGI2 in angiogenesis. Exp. Cell Res. 266: 33-43
- G.Bartolini, K.Ammar, B.Mantovani, F.Bonafè, C.Gualandi, M.L.Verzelli e M.Orlandi 2000 Prostaglandin E2 synthesis in colon cancer cell lines: effect of retinoids. Proc. XI International Conference on Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications. Firenze (Italy), June 4-8 -
- A.Quaglia, M.Orlandi, G.Bartolini, M.L.Verzelli e D.Minelli 2000 Aspetti morfo-funzionali dell’apoptosi nelle cellule ematiche di Anguilla anguilla (Osteichthies, Actinopterygii). Biol. Mar. Medit. 7: 914-916
- A.Quaglia, M.Orlandi, G.Bartolini, M.L.Verzelli e D.Minelli. 1999 Aggregazione dei trombociti in Anguilla anguilla (Osteichthies, Actinopterygii). Biol. Mar. Medit. 6: 725-727
- C.Griffoni, E.Spisni, M.Orlandi, S.Santi, M.Riccio e Vittorio Tomasi. 1999 A 38 kDa nuclear protein is involved in the retention of an antisense oligonucleotide directed against cytosolic phospholipase A2. Nucleos. Nucleot. 18: 1673-1676
Postgraduate training :
- PhD programme in Molecular Physiology and Structural Biology
Collaborations :
Cancerology : Cancerology team (Prof. Paola Rocchi, Prof. Anna Maria Ferreri)
Experimental Pathology : Department of Experimental Pathology, University of Bologna (Italy)
Links :
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Research group :
GIOVANNA BARTOLINI (Associate professor)
MARINA ORLANDI (Research Associate)
ALESSIO PAPI (PhD student)
