Unit of Developmental genetics
Lab of Genetica Molecolare
tel. +0512094184
fax +0512094286
Group Leader: Giuseppe Gargiulo
E-mail : giuseppe.gargiulo@unibo.it
Research in progress :
- By using direct and reverse genetics approaches, the research carried out in my lab are mainly focused on the analysis of Drosophila development and the use of Drosophila as model system to study the function of heterologous genes expressed during Drosophila development. The ongoing projects are: - analysis of signaling pathways involved in the progression of the oogenetic processes that lead to the production of a mature eggs. - analysis of molecular mechanisms in germ cell establishment in Drosophila - use of Drosophila as model system to perform a functional analysis of human disease genes expressed in Drosophila transgenic lines. - use of Drosophila as model system to study the interactions between parasitoids and their hosts by expressing parasitoids transgenic genes during Drosophila development. This analysis will be relevant to develop biotechnology-derived natural products for pest control.
Funding :
- The work has been financed from MIUR, and presently he has been in charge of a project based on the use of Drosophila as model system to study the interaction between host-parasitoid in the insect. By collaborating with Prof. Paul Lasko, Chiarman of the Department of Biology and Developmental Biology, McGill University, Montreal, Québec, Canada, in the 2007 Prof. Gargiulo obtained a grant from the Italian Ministry of Foreing Affairs for the project: “Molecular mechanisms in germ cell establishment and diseases” nell'ambito dei Progetti di Ricerca di Grande Rilevanza (legge 401/1990) approvati nei protocolli di Cooperazione Scientifica e Tecnologica Bilaterale Italia-Quebec (2007-2009).
- PRIN 2004-2006 (MIUR) "Nuove strategie di controllo degli insetti con geni di antagonisti naturali".
Patents :
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Selected Publications :
- F. Bernardi, P. Romani, G. Tzertzinis, G. Gargiulo, and V. Cavaliere 2009 EcR-B1 and Usp nuclear hormone receptors regulate expression of the VM32E eggshell gene during Drosophila oogenesis Developmental Biology 328:541–551
- P. Romani, F. Bernardi, J. Hackney Jennifer, L. Dobens, G. Gargiulo, and V. Cavaliere 2009 Cell survival and polarity of Drosophila follicle cells require the activity of Ecdysone Receptor B1 isoform Genetics 181:165-175
- V. Cavaliere, F. Bernardi, P. Romani, S. Duchi and G. Gargiulo 2008 Building up the Drosophila eggshell: first of all the eggshell genes must be transcribed Developmental Dynamics 237:2061-2072
- B. Levine, M. Jean-Francois, F. Bernardi, G. Gargiulo, and L. Dobens 2007 Notch signaling links interactions between the C/EBP homolog slow border cells and the GILZ homolog bunched during cell migration. Developmental Biology 305: 217-231.
- F. Bernardi, S. Duchi, V. Cavaliere, A. Donati, D. Andrenacci, and G. Gargiulo 2007 Egfr signaling modulates VM32E gene expression during Drosophila oogenesis. Dev. Genes & Evolution 217: 529-540.
- Bernardi F, Cavaliere V, Andrenacci D, Gargiulo G. 2006 Dpp signaling down-regulates the expression of VM32E eggshell gene during Drosophila oogenesis. Developmental Dynamics 235:768-775
- Cavaliere V, Donati A, Hsouna A, Hsu T, Gargiulo G. 2005 dAkt kinase controls follicle cell size during Drosophila oogenesis. Developmental Dynamics 232: 845-854 (I.F. 3.160)
- Gigliotti S, Cavaliere V , Gargiulo G , Graziani F , Malva C. 2004 Molecular genetics of oogenesis in Drosophila melanogaster. ISJ 1: 72-81
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Postgraduate training :
- Ph.D. Program in Cellular, Molecular and Industrial Biology (Project n. 1: Physiology and Cellular Biology)
- Fellowships on specific research projects
Collaborations :
-Prof. Tien Hsu, : Department of Pathology and Laboratory Medicine, and Hollings Cancer Center, Medical,University of South Carolina, Charleston, USA
-Dr. Franco Graziani, : Istituto di Genetica e Biofisica, CNR, Napoli, Italy
-Prof. Leonard L. Dobens : Division of Molecular Biology and Biochemistry University of Missouri, Kansas City, USA
- : Prof. Paul Lasko, McGill University, Montreal, Québec, Canada.
-Prof. Francesco Pennacchio, : Università di Napoli "Federico II", Portici, Italy.
-Dr. Franco Graziani : Istituto di Genetica e Biofisica "Adriano Buzzati-Traverso", Napoli, Italy.
Links :
Postgraduate training
hhttp://www.dipartimentobiologia.it/doctoraltraining/gargiulo.asp
flybase
http://flybase.bio.indiana.edu/
BDGP
http://www.fruitfly.org/DGC/index.html
Research group :
Giuseppe Gargiulo (Full Professor)
Patrizia Romani PhD student
Santi Pellegrino Student
Marilena Barraco Student
Valeria Cavaliere (Research Associate)
