Unit of Applied genetics
Lab of Applied Molecular Genetics
tel. +++39.051.209 4202/4181
fax +++39.051.209 4286
Group Leader: Brunella Del Re, Gianfranco Giorgi
E-mail : brunella.delre@unibo.it - gianfranco.giorgi@unibo.it
Research in progress :
- The transposable elements (TEs) influence genomic structure and function. Under physiological conditions, TE mobility is usually tightly regulated. However, they are a major source of genetic diversity, and allow living organisms to respond to environmental changes. Our research group aims to study the regulation of TE mobility under various stress conditions, in particular upon exposure to extremely low frequency magnetic fields (ELF-MF). Various conditions are being tested, such as different exposure times to ELF-MFs having different flux densities and waveforms (square, sinusoidal) and simultaneous exposure to other stresses, on different TE models (Tn10 in bacteria cells, LINEs in human cell line).
Funding :
- CNR-ENEA-MIUR "Salvaguardia dell'uomo e dell'ambiente dalle emissioni elettromagnetiche".
- PRIN 2006-2007 (MIUR): Effects of elettromagnetic fields on nervous cells.
- PSA - Progetto Strategico di Ateneo 2007
- PRIN 2008-2009 (MIUR): Effects of elettromagnetics fields on nervous cells
Patents :
Selected Publications :
- Brunella Del Re, Ferdinando Bersani, Pietro Mesirca, Gianfranco Giorgi. 2006 Synthesis of DnaK and GroEL in Escherichia coli cells exposed to different magnetic field signals. Bioelectrochemistry 69: 99–103.
- Del Re B, Bersani F, Agostini C, Mesirca P, Giorgi G. 2004 Various effects on transposition activity and survival of Escherichia coli cells due to different ELF-MF signals Radiat. Environ. Biophys. 43:237-245
- Del Re B, Bersani F, Agostini C, Mesirca P, Giorgi G. 2003 june 22-27 Different ELF-MF signals affect differently the transposition activity in Escherichia coli. Twenty-fifth Annual Meeting Technical Program & Registration. Wailea Marriott, Maui, Hawaii p 25
- Del Re B, Garoia F, Mesirca P, Agostani C, Bersani F, Giorgi G. 2003 Extremely low frequency magnetic fields affect transposition activity in Escherichia coli Radiat. Environ. Biophys. 42:113-118
- Ferrarini V, Del Re B, Pasini L, Parini C, Biavati B, Sgorbati B. 2003 Construction of a genomic library in Bifidobacterium longum B2 Annals of Microbiology 53: 505-310
- Del Re B, Sgorbati B, Miglioli M, Palenzona DL 2000 Adhesion, autoaggregation and hydrophobicity of 13 strains of Bifidobacterium longum Letters in Applied Microbiology 31: 438-442
- Giorgi G. 2000 A novel protein which is expressed in the embryo and larva of Drosophila melanogaster: sequence of the cDNA Accession to NCBI number AF225958
- Giorgi G, Cavicchi S, Bersani F. 1999 Evidence of changes in genomic location of transposable elements in Drosophila melanogaster flies exposed to static magnetic fields Kluwer Academic/Plenum Publishing. New York. 687-690
Postgraduate training :
- -
Collaborations :
methodologies related to electromagnetic fields : Prof. F. Bersani, Professor of Health Physics, Faculty of Medicine, University of Bologna (Italy) for methodologies related to electromagnetic fields, in particular NIR.
Links :
Dip. Fisica Sezione 6.10
http://www.df.unibo.it/ricerca/annuario/ric6.asp?sezione=2x25
Progetto MURST-CNR-ENEA
http://www.emprotect.enea.it/
Genoma E. coli K12
http://www.ncbi.nlm.nih.gov/genomes/altik.cgi?db=G&gi=115
Research group :
Brunella Del Re (Research Associate)
Gianfranco Giorgi (Research Associate)
